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MCQ on anticancer agents: Page-1

Which of the following anticancer agent works as cell-cylce specific?

(A) P,R

(B) Q,S

(C) P,Q

(D) R,S

The drug corresponding to letter ‘O’ in the R-CHOP regimen used for chemotherapy of lymphocytic leukemia is

(A) Omalizumab

(B) OndanPageron

(C) Vincristine

(D) Prednisone

R-CHOP is a multi drug regimen that includes rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone. Hydroxydaunorubicin is also called as doxorubicin and oncovin as vincristine.

Which of the following is a prodrug

(A) P

(B) Q

(C) R

(D) P,S

Dacarbazine in vivo converted into methyltriazenoimidazole carboxamide that acts as alkylating agent and produces methylation of O6 of guanine in DNA.

Select the INCORRECT statement

(A) The resistance towards 6-MP is due to alteration of HGPRT

(B) Allopurinol increases the action of 6-MP

(C) Azathioprine is prodrug of 6-MP

(D) 6-MP is given with leucovorin

6-MP can be metabolized by xanthine oxidase enzyme to thiouric acid which is inhibited by allopurinol. Hence allopurinol may increase the levels of methotrexate leading to its toxicity. 6-MP requires bioactivation into 6-thioinosinic acid by the enzyme hypoxanthine-guanine phosphoribosyl transferase

Select the INCORRECT statement

(A) Leucovorin is given along with 5-FU to decrease megaloblastic anemia

(B) Capecitabine is a prodrug of 5-FU converted by tumor specific thymidine phosphorylase

(C) The dose of 5-FU should be reduced in dihydropyridine dehydrogenase deficient patients

(D) Cytarabine inhibits DNA polymerase

Dihydropyridine dehydrogenase is responsible for metabolism of 5-fluorouracil. Patients who are deficient in DPD will have elevated levels of 5-FU in blood leading to its toxicity. Hence the dose of 5-FU should be individualized based on the DPD levels in the patient. Capecitabine is a prodrug of 5-FU. Methotrexate produces megaloblastic anemia and requires leucovorin supplement.