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MCQ on antianginal agents: Page-2

The drug which is a both arterial and venous dilator

(A) P,S

(B) R

(C) Q

(D) P,Q

Nicorandil acts by opening of potassium channels as well as release of nitric oxide . Hence it acts as both arterial and venous vasodilator. Nitroglycerine is an organic nitrate mainly acts as venous vasodilator. Nifedipine is a calcium channel blocker that mainly produces arteolar vasodilatation.

Which of the following drug has short duration of action

(A) Nitroglycerine

(B) Isosorbide mononitrate

(C) Amyl nitrite

(D) Isosorbide dinitrate

The order of duration of action and even onPage of action follows the following order. Amylnitrite < Nitroglycerine < Isosorbide dinitrate < Isosorbide mononitrate. But amylnitrite is actually used for cyanide poisoning not for angina.

Which of the following belongs to dihydropyridine category

(A) Nicorandil

(B) Nifedipine

(C) Amiloride

(D) Amiodarone

Nifedipine belongs to dihydropyridines. The suffix dipine indicates that they belongs to dihydropyridines.

All of the following are short acting except

(A) Amlodipine

(B) Nifedipine

(C) Verapamil

(D) Diltiazem

Both amlodipine and nifedipine belongs to dihydropyridines. Amlodipine is a long acting dihydropyridine.

The drug which is more selective for cardiac muscle is

(A) Diltiazem

(B) Verapamil

(C) Nifedipine

(D) Nimodipine

Calcium channel blockers chemically belong to three classes. Verapamil is a phenylalkylamine, diltiazem is a benzothiazepine and nifedipine, nimodipine are dihydropyridines. Among these verapamil is selective for cardiac muscle whereas dihydropyridines are selective for smooth muscle. Diltiazem acts on both cardiac as well as smooth muscle.