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MCQ on antiarrhythmic agents: Page-6

Identify the possible side effects of amiodarone from the following
side effects of amiodarone

(A) P,R,S

(B) Q,R,S

(C) Q,R

(D) P,Q,S

Amiodarone causes slate grey-blue discoloration, pulmonary fibrosis, corneal deposits, optic neuritis, hepatotoxicity and thyroid abnormalities such as hypo or hyperthyroidism. This is due to iodine moiety present in its structure. It does not produce bone marrow depression as it has no action on cell cycle.

The drug which is indicated for the wolf-parkinson-white syndrome is

(A) Amiodarone

(B) Lidocaine

(C) Nifedipine

(D) disopyramide

Amiodarone is a drug of choice for wolf-parkinson-white syndrome as it is a re-entry type of arrhythmia.

Calcium channel blockers are contraindicated in

(A) Heart failure

(B) Ventricular arrhythmias

(C) Hypertension

(D) Angina

Calcium is very important for contraction of heart. Drugs that block these channels on the heart decrease the force of contraction of the heart hence contraindicated in heart failure.

Which of the following endogenous mediator can be used for supraventricular tachycardia

(A) Adenosine

(B) Anandamine

(C) Opioid peptides

(D) Adrenaline

Adenosine is a endogenous purine mediator that is indicated for SVT

Which of the following statement is CORRECT

(A) Dronedarone has more thyroid abnormalities and less pulmonary fibrosis than amiodarone

(B) Dronedarone has less thyroid abnormalities and more pulmonary fibrosis than amiodarone

(C) Dronedarone has more thyroid abnormalities and more pulmonary fibrosis than amiodarone

(D) Dronedarone has less thyroid abnormalities and less pulmonary fibrosis than amiodarone

Dronedarone does not have iodine moiety hence doesn’t show thyroid abnormalities and pulmonary fibrosis.