Amiodarone causes slate grey-blue discoloration, pulmonary fibrosis, corneal deposits, optic neuritis, hepatotoxicity and thyroid abnormalities such as hypo or hyperthyroidism. This is due to iodine moiety present in its structure. It does not produce bone marrow depression as it has no action on cell cycle.
Amiodarone is a drug of choice for wolf-parkinson-white syndrome as it is a re-entry type of arrhythmia.
(A) Heart failure
(B) Ventricular arrhythmias
Calcium is very important for contraction of heart. Drugs that block these channels on the heart decrease the force of contraction of the heart hence contraindicated in heart failure.
(C) Opioid peptides
Adenosine is a endogenous purine mediator that is indicated for SVT
(A) Dronedarone has more thyroid abnormalities and less pulmonary fibrosis than amiodarone
(B) Dronedarone has less thyroid abnormalities and more pulmonary fibrosis than amiodarone
(C) Dronedarone has more thyroid abnormalities and more pulmonary fibrosis than amiodarone
(D) Dronedarone has less thyroid abnormalities and less pulmonary fibrosis than amiodarone
Dronedarone does not have iodine moiety hence doesn’t show thyroid abnormalities and pulmonary fibrosis.