(A) P stabilizes microtubules in mitosis
(B) Q has less neurotoxicity
(C) R acts as spindle poison
(D) S inhibits topoisomerase I
Vincristine inhibits polymerization of free beta tubules into microtubules hence act as spindle poison. Taxanes like paclitaxel and docetaxel does not inhibit formation of microtubules but cause their stabilization leading to inhibition of mitotic division. Among the vinca alkaloids, vinorelbine is a semi-synthetic agent that produces less neurotoxicity. Etoposide is a podophyllotoxin that inhibits topoisomerase II.
(A) Increased metabolism
(B) Alteration of enzymatic activity
(C) Drug efflux from target tissues
(D) Receptor down regulation
Many mechanism are involved in the development of resistance for anticancer agents. Among these drug efflux by p-glycoprotein is the major mechanism of resistance.
(A) Bleomycin, Pulmonary fibrosis
(B) Methotrexate, Paraesthesias
(C) Doxorubicin, Cardiotoxicity
(D) Cyclophosphamide, Haemorrhagic cystitis
Vinca alkaloids produce parasthesias. Methotrexate produces megaloblastic anemia.
(A) Exemestane, aromatase inhibitor
(B) Dactinomycin, DNA polymerase inhibitor
(C) Etoposide, Topoisomerase II
(D) Pentostatin, RNA polymerase inhibitor
Pentostatin inhibits adenosine deaminase enzyme which converts adenosine to inosine.
(A) Irinotecan, topoisomerase I
(B) Rituximab, HER2 antibody
(C) Bevacizumab, vascular endothelium growth factor
(D) Dactinomycin, DNA polymerase inhibitor
Rituximab acts against CD20 antigen that is expressed on B lymphocytes.