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MCQ on antitubercular agents: Page-2

Select the drug indicated for extended drug resistance tuberculosis (XDR TB)
linezolid

(A) P

(B) Q

(C) R

(D) S

For extended drug resistance tuberculosis drugs such as clofazimine and linezolid can be added to regimen.

Which of the following is TRUE regarding multi drug therapy (MDT) of tuberculosis

(A) Continuous phase  is Isoniazid + Rifampicin+pyrazinamide for 2 months

(B) Initial phase is Isoniazid + Rifampicin for 4 months

(C) Initial phase is  Isoniazid + Rifampicin + Pyrazinamide + Ethambutol for 2 months

(D) Continuous phase is  Dapsone + Rifampicin for 6 months

Various MDR regimens are available for 9 months to 2 years based on the progression of disease. One of the recommended regimen includes 6 months treatment with two phases. Initial phase is for two months with Isoniazid + Rifampicin + Pyrazinamide + Ethambutol in the regimen and continuous phase is for 4 months with Isoniazid + Rifampicin in the regimen.

A 45 year old male HIV patient suffering was developed tuberculosis infection recently. He is under HAART therapy with saquinavir as one of the drug in regimen. Which of the following drug is less preferred to be added in to regimen for tuberculosis

(A) Isoniazid

(B) Rifampin

(C) Pyrazinamide

(D) Ethambutol

Rifampin is an enzyme inducer and can increase the metabolism of protease inhibitor like saquinavir resulting in failure of HIV treatment. Rifabutin should be added in to regimen instead of rifampin as the former is not an enzyme inducer and has less drug interactions.

A 25 year old female is under DOT treatment for tuberculosis. She reports that she has blurred vision and unable differentiate red and green color. Which of the following drug is likely to produce above effects.

(A) Isoniazid

(B) Rifapentine

(C) Pyrazinamide

(D) Ethambutol

Ethambutol can produce optic neuritis resulting in indiscrimination between red and green color.

Select the WRONG combination of drug and side effect

(A) Isoniazid, optic neuritis

(B) Rifampin, orange-red tinge

(C) Capreomycin, ototoxicity

(D) Pyrazinamide, gout

Various drugs used in TB and their main side effects are as follows. Isoniazid  peripheral neuropathy, hemolytic anemia; Rifampin  Liver failure and orange tinge to saliva and urine ; Pyrazinamide  hyperuricemia ; Ethambutol  Optic neuritis; Cycloserine  neurotoxicity; Capreomycin  ototoxicity; p-Aminosalicylic acid, Ethionamide  Hepatotoxicity and hypothyroidism.