(A) Q,R and S
(B) P and S
(C) P,Q and R
(C) Q and R
Linezolid is an oxazolidinone which inhibits protein synthesis and also has weak MAO inhibitory activity. Hence it should be carefully given with food containing monoamines like tyramine otherwise results in cheese reaction.
Ticarcillin and piperacillin are antipseudomonal penicillins. Ampicillin, amoxicillin and pivampicillin are extended spectrum penicillins. Clavulanic acid is a beta lactamase inhibitor. Among III generation cephalosporins, cefixime is an orally active and ceftazidime, cefotaxime and ceftriaxone are given parenterally.
Imipenem produces nephrotoxicity due to formation of toxic metabolite in renal tubules because of its breakdown in the kidney by dehydropeptidases. This enzyme is inhibited by co-administration with cilastatin hence nephrotoxicity can be prevented.