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MCQ on drugs acting on heart failure: Page-4

Which of the following drugs are cardiotonic agents?

(A) Q,R

(B) P,S

(C) R,S

(D) P,Q

Both dobutamine and digoxin increase force of contraction of heart hence considered as cardiotonic agents. Former acts as agonist on β 1 receptors while later inhibits cardiac pump.

The pain in the ischaemic heart disease is controlled by

(A) Beta blockers

(B) NSAIDs

(C) Local anaesthetics

(D) Opioids

Opioids are generally used to control the pain produced in ischemic heart. NSAIDs as they inhibit prostaglandin synthesis, particularly PG I2, may increase the risk of ischemia. Aspirin is an exception which is used in heart diseases like myocardial infarction as it has additional antiplatelet action by inhibition of thromboxane A2 synthesis.

The muscarinic receptors present on the heart are linked with

(A) Increase in cAMP

(B) Decrease in cAMP

(C) Increase in IP3/DAG

(D) Decrease in IP3/DAG

On heart M2 receptor an beta1 receptors are present. The former coupled with decrease in cAMP whereas later associated with increase in cAMP. Therefore the M2 receptors are inhibitory and beta1 receptors are stimulatory.

Select the drug that can cause yellowish vision in few of the treated patients.

(A) Amiodarone

(B) Digoxin

(C) Clofazimine

(D) Sildenafil

Amiodarone is a potassium channel blocker used for cardiac arrhythmias. It can cause discoloration of skin to grey color. Clofazimine is basically a dye that can result in pinkish skin discoloration. Sildenafil is PDE type V inhibitor that can result in impairment of color discrimination. Digoxin is a cardiac glycoside that can cause yellowish vision in susceptible patients.

Natriuretic peptides play an important role in controlling heart failure. Given below are few of the mechanisms which may affect the condition of heart failure.

Choose the RIGHT statement

(A) R,S are TRUE and P,Q are FALSE

(B) P,R are TRUE and Q,S are FALSE

(C) R is TRUE and P,Q,S are FALSE

(D) R,Q are TRUE and P,S are FALSE