Given below is a mechanism of drug that increases force of contraction in heart failure.
Identify the most appropriate drug from the following.
Salbutamol is a β2 receptor agonist that works by increasing cAMP within the smooth muscle. Its action cardiac muscle is not significant to be indicated as a drug in heart failure. Propranolol is a β blocker that doesn’t increase cAMP. Spironolactone is an aldosterone antagonist that is not related with this mechanism. Finally, dobutamine is a β 2 receptor agonist that specifically acts on cardiac muscle hence indicated for heart failure.
Given below is a ring system present in one of the drug indicated for heart failure. Identify it
Digoxin has significant interaction with all of the following except
Amiodarone, verapamil and spironolactone all inhibit P-glycoprotein thereby decrease urinary excretion of digoxin leading to its toxicity. Nifedipine is a CCB that acts on vascular smooth muscle and has no interaction with digoxin.