Fatty acids are converted in to their triglycerides and absorbed from the intestine as chylomicrons.
(D) Chylomicrons + VLDL
Type IIa with LDL and type IIb with LDL + VLDL
Atherogenesis is a process in which LDL cholesterol it attached to the endothelium which is oxidized into fatty streaks forming atheroma. At the same time, cholesterol released from tissue breakdown is released in to blood stream as HDL leading less formation for atheroma. Therefore LDL cholesterol increases the atherogenesis whereas HDL cholesterol decreases atherogenesis. VLDL is rich in triglycerides hence poses less risk for atherogenesis.
(A) LDL receptors
(B) VLDL receptors
(C) HDL receptors
(D) Chylomicron receptors
Liver will uptake both chylomicrons and LDL. Chylomicron is taken into liver by endocytosis.
(A) Inhibition of HMG-CoA reductase
(B) Inhibition of platelet aggregation
(C) Inhibition of neovascularization
(D) Increased fibrinolysis
Statins inhibit the cholesterol biosynthesis in liver which results in more uptake of LDL cholesterol by increased expression of LDL receptors on liver. Thereby they decrease LDL cholesterol and increase HDL. They also decrease VLDL and triglycerides to a minor extent.