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MCQ on antihyperlipidemics: Page-2

The fatty acid esters and cholesterol are transferred from ileum to lymph and blood as

(A) VLDL

(B) Chylomicrons

(C) HDL

(D) LDL

Fatty acids are converted in to their triglycerides and absorbed from the intestine as chylomicrons.

Familial type IIa hypercholesterolaemia is due to raised levels of

(A) Chylomicrons

(B) LDL

(C) VLDL

(D) Chylomicrons + VLDL

Type IIa with LDL and type IIb with LDL + VLDL

Which of the following lipoproteins pose high risk for atherogenesis

(A) Chylomicrons

(B) LDL

(C) VLDL

(D) HDL

Atherogenesis is a process in which LDL cholesterol it attached to the endothelium which is oxidized into fatty streaks forming atheroma. At the same time, cholesterol released from tissue breakdown is released in to blood stream as HDL leading less formation for atheroma. Therefore LDL cholesterol increases the atherogenesis whereas HDL cholesterol decreases atherogenesis.  VLDL is rich in triglycerides hence poses less risk for atherogenesis.

Which of the following receptors are present on the liver?

(A) LDL receptors

(B) VLDL receptors

(C) HDL receptors

(D) Chylomicron receptors

Liver will uptake both chylomicrons and LDL. Chylomicron is taken into liver by endocytosis.

Statins act by

(A) Inhibition of HMG-CoA reductase

(B) Inhibition of platelet aggregation

(C) Inhibition of neovascularization

(D) Increased fibrinolysis

Statins inhibit the cholesterol biosynthesis in liver which results in more uptake of LDL cholesterol by increased expression of LDL receptors on liver. Thereby they decrease LDL cholesterol and increase HDL. They also decrease VLDL and triglycerides to a minor extent.