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MCQ on antihyperlipidemics: Page-5

Which of the following is uricosuric

(A) Simvastatin

(B) Lovastatin

(C) Gemfibrozil

(D) Fenofibrate

Fenofibrate is uricosuric and increases the excretion of uric acid.

One of the unwanted effect of cholestyramine is

(A) Abdominal bloating

(B) Myositis

(C) Hyperuricaemia

(D) All of the above

Abdominal bloating is a condition in which gases are filled in the abdomen with swelling of abdomen and patient feels fullness of the stomach. Cholestyramine is a bile acid binding resin that forms a macro complex with bile acids resulting in bloating and gastric discomfort.

The main unwanted effect of nicotinic acid is

(A) Reflex bradycardia

(B) constipation

(C) Flushing

(D) Thrombocytopenia

Nicotinic acid is a vasodilator that produces throbbing headache and hypotension. Hence patient should be suggested to take aspirin before administration of niacin.

The drug that inhibits the absorption of cholesterol by forming a complex with bile acids is

(A) Simvastatin

(B) Ezetimibe

(C) Gemfibrozil

(D) Colestipol

Cholestyramine and Colestipol inhibit cholesterol absorption by forming a complex with bile acids. Ezetimibe directly inhibits the intestinal absorption of cholesterol.

Choose the WRONG drug target for atherosclerosis

(A) HMG Co-A reductase inhibitors

(B) Omegalpha-3 fatty acids

(C) Cholesterol absorption inhibitors

(D) Lipoprotein lipase inhibitors

Lipoprotein lipase activators like fibrates are used.