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MCQ on antihyperlipidemics: Page-3

Given below are the list of statins indicated for hyperlipidemia. Identify the prodrugs among them.

(A) P

(B) S

(C) Q and R

(D) P and R

Simvastatin and lovastatin are lactone prodrugs. Remaining all statins are active drugs.

Which among the above listed drugs has long duration of action?

(A) Q

(B) S

(C) P

(D) R and S

Atorvastatin is long acting.

The serious but rare adverse effect of statin is

(A) Neutropenia

(B) Rhabdomyolysis

(C) Bone marrow depression

(D) Haemorrhage

Statins can cause rhabdomyolysis which can cause myalgia

Which of the following drug acts on nuclear receptor

(A) Simvastatin

(B) Clofibrate

(C) Tranexamic acid

(D) alteplase

Clofibrate acts on PPAR receptors which belongs to family of nuclear receptors. Fibrate act on these receptors and increase protein synthesis such as lipoprotein lipase which converts the triglycerides in to free fatty acid. Thus fibrates mainly decrease VLDL and triglycerides.

One of the important action of Fibrates is to

(A) Increase lipoprotein lipase

(B) Increase the transcription factor nuclear factor kappa B

(C) Reduce plasma C-reactive protein

(D) reduce fibrinogen

Fibrates act on PPAR receptors and increase protein synthesis such as lipoprotein lipase which converts the triglycerides in to free fatty acid. Thus fibrates mainly decrease VLDL and triglycerides.