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MCQ on antihypertensives: Page-2

Select the mediators that act as vasoconstrictors from the following.
adrenaline

(A) P and S

(B) Q and R

(C) P,Q and R

(D) Q,R and S

Adenosine is vasodilator that acts by opening of potassium channels.

Which of the following drug increases the contractility of heart?

(A) Amiodarone

(B) Levosimendan

(C) Minoxidil

(D) Nicorandil

Which of the following drug is converted in to cyanide by exposure to light?

(A) Nicorandil

(B) Captopril

(C) Nitroprusside

(D) Valsartan

Sodium nitroprusside is an organic nitrate that is less stable and is easily hydrolysed to cyanide on exposure to light. Hence it should be stored in a dark colored bottle and even it reconstituted before the administration. It is also converted in sodium thiocyanate in the body which on accumulation produces toxicity.

Select PDE type III inhibitor from the following

(A) Theophylline

(B) Milrinone

(C) Chromokalim

(D) Sildenafil

Amrinone and milrinone are PDE type III inhibitors used as cardiac stimulants in treatment of heart failure. Theophylline is a non-selective PDE inhibitor and adenosine receptor antagonist. Sildenafil is a PDE type V inhibitor indicated for erectile dysfunction and pulmonary hypertension.

Which of the following drug acts as PDE V inhibitor

(A) Sildenafil

(B) Cilostazol

(C) Amrinone

(D) Bosentan

Sildenafil is a PDE type V inhibitor indicated for erectile dysfunction and pulmonary hypertension.