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MCQ on antihypertensives: Page-3

Given below are few of the physiological changes effected by few mediators. Select the functiosn that are related to the actions of angiotensin II (AT II).
cell proliferation

(A) Q and R

(B) R and S

(C) P,Q and R

(D) Q,R and S

Angiotensin II released from RAS  in response to low perfusion pressure shows several effects. Angiotensin II is a potent vasoconstrictor which is further increased by its action on sympathetic discharge which release noradrenaline from sympathetic nerve endings. It also increases aldosterone secretion which causes sodium and water retention. On long term, AT II can also stimulate cell proliferation leading to hypertrophy and hyperplasia.

Choose the WRONG drug target for treatment of hypertension

(A) Alpha-2 antagonists

(B) ACE inhibitors

(C) Beta blockers

(D) AT II receptor antagonists

Aplhalpha-2 antagonists are not vasodilators. Alphalpha-1 antagonists are vasodilators.

Select the WRONG combination of drug and its mechanism

(A) Bradykinin, Nitric oxide

(B) Opioids, Increase in cAMP

(C) Natriuretic peptide, cGMP

(D) Minoxidil, opening of KACh

Bradykinin is a vasodilator that increases release of PGI2 and NO

Read the following statements regarding few of the drugs used in hypertension. Select the INCORRECT statement from the following.

(A) Levosimendan increases the contractility of heart

(B) Minoxidil produces hirsutism

(C) Losartan causes dry cough

(D) Hydralazine produces systemic lupus erythematosus

Losartan is ARB that does not cause dry cough. ACE inhibitors only cause dry cough.

Sildenafil is indicated for

(A) Bronchial asthma

(B) Pulmonary hypotension

(C) Renal hypertension

(D) Erectile dysfunction

Sildenafil is a PDE type V inhibitor indicated for erectile dysfunction and pulmonary hypertension.